DNA photolyase repairs the trans-syn cyclobutane thymine dimer.
نویسندگان
چکیده
DNA photolyases catalyze the splitting of the cyclobutane ring joining the two dihydropyrimidines of a pyrimidine dimer by a photoinduced electron-transfer reaction. Previous studies concluded that photolyase repairs only the cis-syn form of the eight stereoisomers of the cyclobutane pyrimidine dimer (Pyr[ ]Pyr). In this study we found that Escherichia coli photolyase binds to the trans-syn-I isomer of T[ ]T with about 10(4)-fold lower affinity than the cis-syn isomer but it repairs it relatively efficiently.
منابع مشابه
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ورودعنوان ژورنال:
- Biochemistry
دوره 32 28 شماره
صفحات -
تاریخ انتشار 1993